Thermo Fisher Scientific VPS8 Polyclonal Antibody
Rabbit polyclonal antibody against human VPS8 for IHC and IHC-P applications. Recognizes recombinant VPS8 protein with high species identity to mouse and rat. Supplied as liquid, 0.2 mg/mL, in PBS with 40% glycerol. For research use only.
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- PA557855
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:500 | - |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human VPS8. Recombinant protein control fragment (Product # RP-96382). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649480 |
Product Specific Information
Immunogen sequence:
EEIYPYIRTL LHFDTREFLN VLALTFEDFK NDKQAVEYQQ RIVDILLKVM VENSDFTPSQ VGCLFTFLAR QLA
Highest antigen sequence identity:
- Mouse: 97%
- Rat: 97%
Target Information
VPS8 plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. It acts as a component of the putative CORVET endosomal tethering complexes involved in Rab5-to-Rab7 endosome conversion, likely implicating MON1A/B. Through binding SNAREs and SNARE complexes, it mediates tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex functions as a Rab5 effector to mediate early endosome fusion, predominantly in APPL1-containing endosomes. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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