Thermo Fisher Scientific PLK1 Polyclonal Antibody
PLK1 단백질을 표적하는 Thermo Fisher Scientific의 고트 폴리클로날 항체로, 인간 시료에 반응하며 Western blot 및 Peptide ELISA 검증 완료. 세포 분열 및 암 연구용으로 적합하며, 안정적인 액상 형태로 -20°C 보관.
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Thermo Fisher Scientific PLK1 Polyclonal Antibody
Applications
- Western Blot (WB): 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-DKLLSSRSASNRLK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932842 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
PLK1 is a serine/threonine kinase that functions in cell mitosis and serves as a marker of cell proliferation. It plays a critical role in carcinogenesis. Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on specific motifs recognized by POLO box domains. PLK1 phosphorylates multiple substrates including BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, and WEE1. It plays a key role in centrosome function and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1, and NINL.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-142184_PLK1_P53350-1_Goat.svg, PA5-142184_PLK1_P53350-1_Goat_PDP.jpeg)
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