Thermo Fisher Scientific Hemoglobin Monoclonal Antibody (7A4)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• MA5-14708 targets Hemoglobin in ELISA, IP, and RIA applications and shows reactivity with Human samples.
• The immunogen is human Hemoglobin.
• Detects Hemoglobin with a predicted molecular weight of approximately 16 kDa.
• Product MA5-14708 is a smaller package size of MIH9505 (formerly sold as a Seradyn product).

Target Information

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci:
5′- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3′.

• The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical.
• These genes differ slightly over the 5′ untranslated regions and introns, but significantly over the 3′ untranslated regions.
• Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of total hemoglobin.
• Alpha chains combine with delta chains to form HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin.
• Alpha thalassemias result from deletions of each of the alpha genes or both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.