Thermo Fisher Scientific TSPO Polyclonal Antibody
TSPO 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot과 Immunocytochemistry에 사용 가능. 합성 human TSPO 펩타이드로 면역화됨. 1 mg/mL 액상 형태로 제공되며 -20°C에서 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human TSPO |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2691509 |
Target Information
Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an indispensable element of the steroidogenic machinery, where it mediates the delivery of cholesterol to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation.
PBR is composed of three subunits: an isoquinoline binding site, a voltage-dependent anion channel, and an adenine nucleotide carrier.
PBR is genetically conserved from bacteria to humans and is widely expressed in peripheral organs, whereas in the brain, it is sparse and mainly located in glial cells.
Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits Leydig cell steroidogenesis by affecting PBR mRNA stability, thus inhibiting PBR expression, cholesterol transport into the mitochondria, and subsequent steroid formation.
A cytoplasmic protein, PRAX-1 (peripheral benzodiazepine receptor-associated protein 1), is found to specifically interact with PBR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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