Thermo Fisher Scientific PYK2 Monoclonal Antibody (5E2D5)
Human PYK2 단백질을 검출하는 Mouse Monoclonal Antibody로, WB, IHC, ELISA에 적합. Recombinant PYK2 fragment(aa815-997)를 면역원으로 사용. 비결합형 액상 형태이며, 4°C 단기 또는 -20°C 장기 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | - |
| ELISA | 1:10,000 | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5E2D5 |
| Immunogen | Purified recombinant fragment of PYK2 (aa815–997) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.03% Sodium Azide |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10984041 |
Product Specific Information
MA5-15407 targets PYK2 in indirect ELISA, IHC, and WB applications and shows reactivity with Human samples.
The immunogen is a purified recombinant fragment of PYK2 (aa815–997) expressed in E. coli.
MA5-15407 detects PYK2 with a predicted molecular weight of approximately 115.8 kDa.
Target Information
PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway.
It regulates actin cytoskeleton reorganization, cell polarization, migration, adhesion, spreading, and bone remodeling.
FAK2 plays roles in humoral immune response regulation, B-cell migration, and signaling downstream of integrin, collagen, immune, G-protein coupled, cytokine, chemokine, and growth factor receptors.
Aberrant FAK2 expression may contribute to cancer cell proliferation, migration, and invasion. Elevated expression has been observed in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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