Thermo Fisher Scientific ARHGAP20 Polyclonal Antibody
Human ARHGAP20 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 등 다양한 연구용에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 뇌, 간, 난소 등에서 발현되는 ARHGAP20 연구에 활용 가능.
- 카탈로그번호
- PA558399
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ARHGAP20 (Product #RP-102834) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638139 |
Product Specific Information
Immunogen sequence:
LSPDFSNASH VSGMPGPSSG QACSRPAYTK KDTMEWHSQM HSVTLHPSTW LRNGVASLKN WSLKKKAKAA RPEEEKIASP KGPLEPPPHA SGVPEANSLQ
- Highest antigen sequence identity to orthologs:
- Mouse: 67%
- Rat: 66%
Target Information
ARHGAP20 is a potent GTPase-activating protein (GAP) that converts Rho-type GTPases into an inactive GDP-bound state.
It contains several functional domains including:
- Pleckstrin homology (PH) domain
- Ras-associating domain
- Rho-GAP domain
- Two Annexin-like (ANXL) repeats
ARHGAP20 acts as a downstream target of Rap1 in neurite outgrowth. Overexpression leads to Rho inactivation, promoting neurite extension in a Rap1-dependent manner.
It functions as a tumor suppressor gene, being inactivated by deletion in breast cancer and by chromosomal translocation in B-cell chronic lymphocytic leukemia.
Additionally, it may be involved in cytoskeletal rearrangements and cell signaling during spermatogenesis.
Expression is predominant in human brain, liver, ovary, and spinal cord, with lower levels in lymph nodes and fetal liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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