Thermo Fisher Scientific CEP290 Polyclonal Antibody
Human CEP290 단백질에 특이적인 Rabbit Polyclonal Antibody로, IHC(P)에서 1:1,000~1:2,500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(glycerol 포함) 용액 형태로 제공. Joubert 증후군 및 여러 암 연구에 활용 가능.
- 카탈로그번호
- PA560550
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:1,000–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CEP290. Recombinant protein control fragment (Product #RP-97890). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639679 |
Product Specific Information
- Immunogen sequence:
QVESINKELE ITKEKLHTIE QAWEQETKLG NESSMDKAKK SITNSDIVSI SKKITMLEMK ELNERQRAEH CQKMYEHLRT SLKQMEERNF ELETKFAELT - Highest antigen sequence identity to orthologs:
- Mouse: 92%
- Rat: 91%
Target Information
This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains, and an ATP/GTP binding site motif A.
The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation.
Mutations in this gene have been associated with Joubert syndrome and nephronophthisis, and antibodies against this protein are linked to several forms of cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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