Thermo Fisher Scientific CEP290 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000-1:2,500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CEP290. Recombinant protein control fragment (Product #RP-97890). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CEP290,uniProtId:O15078-1,ncbiNodeId:9606,antigenRange:1006-1105,antigenLength:2479,antigenImageFileName:PA5-60550_CEP290_O15078-1_Rabbit.svg,antigenImageFileNamePDP:PA5-60550_CEP290_O15078-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2639679

Product Specific Information

Immunogen sequence: QVESINKELE ITKEKLHTIE QAWEQETKLG NESSMDKAKK SITNSDIVSI SKKITMLEMK ELNERQRAEH CQKMYEHLRT SLKQMEERNF ELETKFAELT

Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 91%.

Target Information

This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.