Thermo Fisher Scientific PP2CA/PP2CB Polyclonal Antibody
PP2CA/PP2CB 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot에 적합합니다. Bovine, Human, Mouse, Rat 반응성이 있으며, PBS buffer에 0.08% sodium azide가 포함된 액상 형태입니다. 세포 스트레스 반응 및 MAP kinase 경로 연구에 유용합니다.
- 카탈로그번호
- PA112395
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 5–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | PBS |
| Contains | 0.08% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2170062 |
Target Information
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates and negatively regulates the activities of MAP kinases and MAP kinase kinases. It inhibits activation of p38 and JNK kinase cascades induced by environmental stresses. It can also dephosphorylate cyclin-dependent kinases, suggesting involvement in cell cycle control. Overexpression of this phosphatase has been reported to activate the tumor suppressor gene TP53/p53, leading to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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