Thermo Fisher Scientific MCHR2 Polyclonal Antibody
Human MCHR2 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS 버퍼에 0.1% sodium azide가 포함됨. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 21 µg/mL |
| Immunocytochemistry (ICC/IF) | 10–20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from C-terminus of human MCHR2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2143962 |
Product Specific Information
PA1-31050 detects GPCR MCH2 from human samples.
Target Information
Melanin-concentrating hormone (MCH) is a 19 amino acid cyclic neuropeptide primarily expressed in the hypothalamus. MCH modulates feeding behavior, aggression, anxiety, arousal, and reproductive function in mammals by controlling the release of luteinizing hormone (LH).
The melanin-concentrating hormone receptor (MCHR, also designated SLC-1) is a glycosylated G-protein coupled receptor that migrates between 45–50 kDa on SDS-PAGE. MCHR mediates the effects of MCH through Gai and/or Gaq signaling and is expressed in several brain regions, including the cerebral cortex, amygdala, thalamus, and hypothalamus.
MCH and MCHR have also been implicated in stimulating leptin expression and secretion in adipocytes, suggesting that the melanin-concentrating hormone and its receptor may be potential targets for modulating obesity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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