Thermo Fisher Scientific ZEB1 Monoclonal Antibody (OTI4B8), TrueMAB
인간 ZEB1 단백질(aa 1-350)을 인식하는 Mouse IgG1 단클론 항체로, Western blot에 최적화됨. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol 완충액에 보존. -20°C 보관, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4B8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1-350 of human ZEB1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ZEB1 (Zinc finger E-box-binding homeobox 1)
ZEB1 acts as a transcriptional repressor and inhibits interleukin-2 (IL-2) gene expression. It modulates promoter activity of the ATP1A1 gene depending on cDNA quantity and cell type. ZEB1 represses E-cadherin promoters and induces epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. It also represses BCL6 transcription with CTBP1, regulates neuronal differentiation, and affects RCOR1 transcription during neurogenesis. Mutations in ZEB1 can cause corneal dystrophy, posterior polymorphous corneal dystrophy, and Fuchs endothelial dystrophy.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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