Thermo Fisher Scientific IFI16 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000
• Publications: View 1 publication

Product Specifications

Product Specific Information

PA5-39180 detects IFI16 in WB application with human samples.

Target Information

IFI16 (gamma-interferon-inducible protein 16) binds double-stranded DNA, preferentially recognizing supercoiled and cruciform DNA structures. It is involved in transcriptional regulation and acts as a transcriptional repressor. IFI16 may regulate hematopoietic differentiation through activation of specific target genes and controls cellular proliferation by modulating cell cycle regulatory factors such as p53/TP53 and retinoblastoma protein.

IFI16 also participates in innate immune responses by recognizing viral dsDNA in the cytosol and nucleus. Upon binding viral DNA, IFI16 recruits TMEM173/STING and induces IFN-beta production. It is essential for activating the IFR3 signaling cascade during human herpes simplex virus 1 infection, promoting heterochromatin assembly on viral DNA, and inhibiting viral immediate-early gene expression and replication. Additionally, IFI16 is involved in MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.