Thermo Fisher Scientific NFX1 Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human NFX1 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NFX1,uniProtId:Q12986-1,ncbiNodeId:9606,antigenRange:668-803,antigenLength:1120,antigenImageFileName:PA5-66008_NFX1_Q12986-1_Rabbit.svg,antigenImageFileNamePDP:PA5-66008_NFX1_Q12986-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Lot-Specific

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2663212

Product Specific Information

Immunogen sequence: KELPCTSLKSE DATFMCDKRC NKKRLCGRHK CNEICCVDKE HKCPLICGRK LRCGLHRCEE PCHRGNCQTC WQASFDELTC HCGASVIYPP VPCGTRPPEC TQTCARVHEC DHPVYHSCHS EEKCPPCTFL TQKWC

Highest antigen sequence identity to the following orthologs - mouse 99%, rat 99%.

Target Information

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. NFX1 is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma.MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.