Thermo Fisher Scientific NFX1 Polyclonal Antibody

Thermo Fisher Scientific NFX1 Polyclonal Antibody

Product Specifications

Product Specific Information

Immunogen sequence:
KELPCTSLKSE DATFMCDKRC NKKRLCGRHK CNEICCVDKE HKCPLICGRK LRCGLHRCEE PCHRGNCQTC WQASFDELTC HCGASVIYPP VPCGTRPPEC TQTCARVHEC DHPVYHSCHS EEKCPPCTFL TQKWC

• Highest antigen sequence identity to the following orthologs: mouse 99%, rat 99%.

Target Information

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes.
NFX1 is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro.
The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma.
Three alternative splice variants, each of which encodes a different isoform, have been identified.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: PA5-66008_NFX1_Q12986-1_Rabbit_PDP.jpeg, PA5-66008_NFX1_Q12986-1_Rabbit.svg)