Thermo Fisher Scientific MAST2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
GESGEEDPFP SRDPRSLGPM VPSLLTGITL GPPRMESPSG PHRRLGSPQA IEEAASSSSA GPNLGQSG

Highest antigen sequence identity to the following orthologs:

• Mouse: 46%
• Rat: 46%

Target Information

Syntrophin is an adapter protein that binds signaling molecules to the dystrophin-associated protein complex, which connects the extracellular matrix to the intracellular cytoskeleton for postsynaptic structure maintenance in neuromuscular junctions and the CNS.
Microtubule-associated serine/threonine-protein kinase 2 (MAST205) is a testis-specific cytoplasmic protein involved in spermatid maturation via a multi-protein complex.
MAST205 links the dystrophin/utrophin network with microtubule filaments through Syntrophin and regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, leading to inhibition of TRAF6 NF-kappa-B activation.
Two isoforms exist due to alternative splicing: Isoform 1 (full-length) and Isoform 2 (lacking residues 327–396 and 1091–1113). The N-terminus phosphorylation is required for ubiquitination and subsequent proteasome-mediated degradation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.