Thermo Fisher Scientific GBP5 Polyclonal Antibody

Applications and Tested Dilutions

Immunohistochemistry (Paraffin) (IHC (P))

• Dilution: 1:5,000–1:10,000

Immunocytochemistry (ICC/IF)

• Concentration: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
TDQALTETEK KKKEAQVKAE AEKAEAQRLA AIQRQNEQMM QERERLHQEQ VRQMEIAKQN WLAEQQKMQE QQMQEQAAQL STTFQAQNRS LLSELQHAQR TVNNDDPCVL L

Target Information

Guanylate-binding proteins (GBPs) are interferon-induced GTP-binding proteins involved in innate immunity against microbial and viral pathogens. In humans, there are seven GBPs (hGBP1–hGBP7).

• GBP1 and GBP2: Exhibit antiviral activity and regulate inhibition of proliferation and invasion of endothelial cells in response to interferon (IFN).
• GBP5: Promotes selective NALP3 inflammasome responses to pathogenic bacteria and soluble, but not crystalline, inflammasome priming agents.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.