Thermo Fisher Scientific WWTR1 Monoclonal Antibody (OTI1B5), TrueMAB
WWTR1 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체로, Western blot, ICC/IF, Flow Cytometry에 사용 가능. 인간 시료에 반응하며, 액상 형태로 제공되고 -20°C에서 보관. Hippo 신호 경로 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B5 |
| Immunogen | Full length human recombinant protein of human WWTR1 produced in HEK293 cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.67 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator that acts as a downstream regulatory target in the Hippo signaling pathway. This pathway plays a crucial role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
The core of this pathway involves a kinase cascade where STK3/MST2 and STK4/MST1, in complex with SAV1, phosphorylate and activate LATS1/2 along with MOB1. MOB1 subsequently phosphorylates and inactivates YAP1 and WWTR1/TAZ.
WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation, regulates nuclear accumulation of SMADS, and couples them to transcriptional machinery such as the mediator complex. It also regulates embryonic stem-cell self-renewal and promotes cell proliferation and epithelial-mesenchymal transition.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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