Thermo Fisher Scientific WWTR1 Monoclonal Antibody (OTI1B5), TrueMAB
WWTR1 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체로, Western blot, ICC/IF, Flow Cytometry에 사용 가능. 인간 시료에 반응하며, 액상 형태로 제공되고 -20°C에서 보관. Hippo 신호 경로 연구에 적합.
✨AI 추천 연관 상품
AI가 분석한 이 상품과 연관된 추천 상품들을 확인해보세요
연관 상품을 찾고 있습니다...
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B5 |
| Immunogen | Full length human recombinant protein of human WWTR1 produced in HEK293 cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.67 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator that acts as a downstream regulatory target in the Hippo signaling pathway. This pathway plays a crucial role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
The core of this pathway involves a kinase cascade where STK3/MST2 and STK4/MST1, in complex with SAV1, phosphorylate and activate LATS1/2 along with MOB1. MOB1 subsequently phosphorylates and inactivates YAP1 and WWTR1/TAZ.
WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation, regulates nuclear accumulation of SMADS, and couples them to transcriptional machinery such as the mediator complex. It also regulates embryonic stem-cell self-renewal and promotes cell proliferation and epithelial-mesenchymal transition.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
🏷️Thermo Fisher Scientific 상품 둘러보기
동일 브랜드의 다른 상품들을 확인해보세요
Thermo Fisher Scientific
Thermo Fisher Scientific PGAM2 Monoclonal Antibody (OTI3B11), TrueMAB
600,200원
Thermo Fisher Scientific
Thermo Fisher Scientific CCM2 Monoclonal Antibody (OTI3B7), TrueMAB
600,200원
Thermo Fisher Scientific
Thermo Fisher Scientific WWTR1 Monoclonal Antibody (OTI1B5), TrueMAB
600,200원
Thermo Fisher Scientific
Thermo Fisher Scientific DLD Monoclonal Antibody (OTI5G7), TrueMAB
626,600원
Thermo Fisher Scientific
Thermo Fisher Scientific CYP17A1 Monoclonal Antibody (OTI9H4), TrueMAB
600,200원
배송/결제/교환/반품 안내
배송 정보
| 기본 배송비 |
| 교환/반품 배송비 |
|
|---|---|---|---|
| 착불 배송비 |
| ||
| 교환/반품 배송비 |
| ||
결제 및 환불 안내
| 결제수단 |
|
|---|---|
| 취소 |
|
| 반품 |
|
| 환급 |
|
교환 및 반품 접수
| 교환 및 반품 접수 기한 |
|
|---|---|
| 교환 및 반품 접수가 가능한 경우 |
|
| 교환 및 반품 접수가 불가능한 경우 |
|
교환 및 반품 신청
| 교환 절차 |
|
|---|---|
| 반품 절차 |
|