Thermo Fisher Scientific MTM1 Polyclonal Antibody
Human MTM1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 용액에 40% glycerol과 0.02% sodium azide를 포함합니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MTM1. Recombinant protein control fragment (Product #RP-92238). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644269 |
Product Specific Information
Immunogen sequence:
KFNVDGWTVY NPVEEYRRQG LPNHHWRITF INKCYELCDT YPALLVVPYR ASDDDLRRVA TFRSRNRIPV LSWIHPENKT VIVRCSQPLV GMSGKRNKDD EKYLDVIRET NKQISKLTIY DARPSVNAVA NK
Highest antigen sequence identity to the following orthologs:
- Mouse: 93%
- Rat: 84%
Target Information
Human MTM1 is a 603 amino acid protein mutated in myotubular myopathy. The related protein hMTMR2 is mutated in a recessive form of Charcot-Marie-Tooth neuropathy.
Myotubularin functions as a lipid phosphatase acting on phosphatidylinositol 3-monophosphate, regulating the PI3-kinase pathway and membrane trafficking. Wild-type myotubularin can dephosphorylate PI 3-P and PI 4-P in vitro, thereby decreasing PI 3-P levels by down-regulating PI3-K activity and promoting PI 3-P degradation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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