Thermo Fisher Scientific NOX2 Polyclonal Antibody
Thermo Fisher Scientific의 NOX2 Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 Western blot, IHC, ICC, ELISA에 사용 가능. Rabbit IgG 폴리클로날 항체로, 액상 형태이며 고순도 친화 크로마토그래피로 정제됨. 세포막 단백질 NOX2 검출에 적합.
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- PA5120443
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 385–570 of human NOX2/gp91phox (NP_0003882) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.95 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914015 |
Product Specific Information
Positive test controls include U-87MG, HL-60, and mouse spleen.
Target localization: Cell membrane, multi-pass membrane protein.
Immunogen sequence:
IAVDGPFGTA SEDVFSYEVV MLVGAGIGVT PFASILKSVW YKYCNNATNL KLKKIYFYWL CRDTHAFEWF ADLLQLLESQ MQERNNAGFL SYNIYLTGWD ESQANHFAVH HDEEKDVITG LKQKTLYGRP NWDNEFKTIA SQHPNTRIGV FLCGPEALAE TLSKQSISNS ESGPRGVHFI FNKENF
Target Information
Mox1 and gp91-phox are essential components of the NADPH oxidase complex, responsible for superoxide generation. This complex is expressed in phagocytes, neuroepithelial bodies, vascular smooth muscle, and endothelial cells.
It includes membrane-bound flavocytochrome subunits (gp91-phox and p22-phox) and cytosolic proteins (p47-phox and p67-phox).
Both gp91-phox and p22-phox act as oxygen sensors that initiate cellular signaling under hypoxic conditions.
Mox1 and gp91-phox share identical C-terminal sequences but differ in tissue expression: gp91-phox in eosinophils, neutrophils, monocytes, and B-lymphocytes; Mox1 mainly in the colon, with low levels in uterus and prostate.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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