Thermo Fisher Scientific Humanin Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to amino acids 9-24 (LLLLTSEIDLPVKRRA) of human Humanin conjugated to KLH at the N-terminus. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Humanin,uniProtId:Q8IVG9-1,ncbiNodeId:9606,antigenRange:9-24,antigenLength:24,antigenImageFileName:28106-100UG_Humanin_Q8IVG9-1_Rabbit.svg,antigenImageFileNamePDP:28106-100UG_Humanin_Q8IVG9-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.0 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Humanin is a novel 24 A. A polypeptide identified in Alzheimers disease-affected brain. It is 99% homologous to mitochondrial 16s ribosomal RNA and functions as a novel neuroprotective and cytoprotective factor. It specifically inhibits neuronal cell death induced by beta-amyloids and Alzheimers disease causing FAD genes by competitively inhibiting access of FPRL1 receptor to beta-amyloids. It acts as an anti-apoptotic factor by binding to Bcl-2/Bax family of pro-apoptotic factors including Bax, Bak, Bid and BimEL and inhibits their pro-apoptotic activity. It activates JAK/STAT signaling pathway and is regulated by TRIM11. It interacts with IGFBP-3 and specifically blocks IGFBP-3 induced cell death in glioblastoma cells. Humanin is also expressed in colon and testis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.