Thermo Fisher Scientific RNF20 Polyclonal Antibody
RNF20 단백질을 인식하는 Rabbit 폴리클로날 항체로, Western blot 및 Immunoprecipitation에 적합합니다. E3 유비퀴틴 리가아제 RNF20의 연구용으로 사용되며, 액상 형태로 4°C에서 보관합니다. 연구용 전용 제품입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of Human Ring Finger 20 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
RNF20 is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B.
It selectively suppresses the expression of proto-oncogenes and growth-related genes, including those induced by epidermal growth factor, by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS).
Conversely, RNF20 positively regulates the p53 tumor suppressor and numerous histone H2A and H2B genes.
Together with the deubiquitinase USP44, RNF20 regulates stem cell differentiation by modulating H2B monoubiquitination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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