Thermo Fisher Scientific Human DC-SIGN (ED) Synthetic Peptide
인간 DC-SIGN(ED) 영역의 17개 아미노산 서열을 기반으로 한 합성 펩타이드로, PA5-19967 폴리클로날 항체의 블로킹 펩타이드로 사용 가능. Assay-dependent 조건에서 활용되며, PBS(pH 7.2) + 0.1% BSA 용액에 200 µg/mL 농도로 제공. 연구용으로만 사용.
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Thermo Fisher Scientific Human DC-SIGN (ED) Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the extracellular domain of human DC-SIGN (ED).
PEP-0092 can be used as a blocking peptide with polyclonal antibody PA5-19967.
Target Information
The DC-SIGN gene encodes a transmembrane receptor expressed on dendritic cells and macrophages. It plays a key role in the innate immune system by recognizing diverse pathogens including parasites and viruses.
The protein has three domains:
- N-terminal transmembrane domain
- Tandem-repeat neck domain
- C-type lectin carbohydrate recognition domain
The extracellular region (neck and C-type lectin domains) functions as both a pathogen recognition receptor and a cell adhesion receptor. The neck domain enables homo-oligomerization, enhancing multivalent ligand binding.
Variations in the neck domain repeat number can affect ligand-binding ability. This gene is closely related to L-SIGN (GeneID 10332), differing in ligand-binding and expression patterns.
Alternative splicing produces multiple variants.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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