Thermo Fisher Scientific EIF4EBP2 Monoclonal Antibody (2G8)
EIF4EBP2 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal 항체로, Western blot과 ELISA에 적합합니다. 고순도 Affinity chromatography로 정제되었으며 PBS buffer에 보존제가 없는 액상 형태입니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2G8 |
| Immunogen | EIF4EBP2 (NP_004087, 61–120 a.a.) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
DRRNSPMAQT PPCHLPNIPG VTSPGTLIED SKVEVNNLNN LNNHDRKHAV GDDAQFEMDI
Target Information
PHAS-II (eIF4E-binding protein II) is involved in translation initiation. It is most abundant in liver and kidney. PHAS proteins bind to eIF-4E, the mRNA cap-binding protein, and inhibit translation of capped mRNA both in vitro and in cells. Phosphorylation at specific sites promotes dissociation of PHAS/eIF-4E complexes, allowing eIF-4E to bind eIF-4G (p220), thereby increasing eIF-4F complex formation and translation initiation rate. The mTOR/p70S6K pathway regulates PHAS-I and -II, suggesting that PHAS proteins mediate its effects on protein synthesis and cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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