Thermo Fisher Scientific EIF4EBP2 Monoclonal Antibody (2G8)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
DRRNSPMAQT PPCHLPNIPG VTSPGTLIED SKVEVNNLNN LNNHDRKHAV GDDAQFEMDI

Target Information

PHAS-II (eIF4E-binding protein II) is involved in translation initiation. It is most abundant in liver and kidney. PHAS proteins bind to eIF-4E, the mRNA cap-binding protein, and inhibit translation of capped mRNA both in vitro and in cells. Phosphorylation at specific sites promotes dissociation of PHAS/eIF-4E complexes, allowing eIF-4E to bind eIF-4G (p220), thereby increasing eIF-4F complex formation and translation initiation rate. The mTOR/p70S6K pathway regulates PHAS-I and -II, suggesting that PHAS proteins mediate its effects on protein synthesis and cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.