Thermo Fisher Scientific IKK beta Polyclonal Antibody

Thermo Fisher Scientific IKK beta Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
PNGCFKALDD ILNLKLVHIL NMVTGTIHTY PVTEDESLQS LKARIQQDTG IPEEDQELLQ EAGLALIPDK PATQCISDGK LNEGHTLDMD LVFLFDNSKI TYETQISPRP QPESVSCILQ EPKRNLAFFQ LRKVWGQVWH

Target Information

Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex.
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kappa-B signaling pathway, activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damage, or other cellular stresses.
IKK beta acts as part of the canonical IKK complex, phosphorylating inhibitors of NF-kappa-B on critical serine residues, enabling polyubiquitination and degradation by the proteasome.
Free NF-kappa-B then translocates into the nucleus, activating transcription of genes involved in immune response, growth control, and protection against apoptosis.
Mutations affecting the IKK beta gene can result in Immunodeficiency 15 (IMD15).

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.