Thermo Fisher Scientific IKK beta Polyclonal Antibody
Human IKK beta 인식 Rabbit Polyclonal Antibody로 Western blot, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존. NF-κB 신호전달 연구용으로 적합.
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Thermo Fisher Scientific IKK beta Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human IKBKB (Product #RP-99395) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_2789088 |
Product Specific Information
Immunogen sequence:
PNGCFKALDD ILNLKLVHIL NMVTGTIHTY PVTEDESLQS LKARIQQDTG IPEEDQELLQ EAGLALIPDK PATQCISDGK LNEGHTLDMD LVFLFDNSKI TYETQISPRP QPESVSCILQ EPKRNLAFFQ LRKVWGQVWH
Target Information
Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex.
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kappa-B signaling pathway, activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damage, or other cellular stresses.
IKK beta acts as part of the canonical IKK complex, phosphorylating inhibitors of NF-kappa-B on critical serine residues, enabling polyubiquitination and degradation by the proteasome.
Free NF-kappa-B then translocates into the nucleus, activating transcription of genes involved in immune response, growth control, and protection against apoptosis.
Mutations affecting the IKK beta gene can result in Immunodeficiency 15 (IMD15).
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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