Thermo Fisher Scientific SERPINB2 Monoclonal Antibody (OTI4E6), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

PAI-2 is an inhibitory serpin expressed mainly in keratinocytes, activated monocytes, and placental trophoblasts. It exists predominantly as a 47 kDa nonglycosylated intracellular protein, which can be secreted as a 60 kDa glycoprotein. Both forms effectively inhibit urokinase-type plasminogen activator (uPA).
PAI-2 can form dormant polymers spontaneously under physiological conditions, possibly aiding controlled release from producing cells. Plasma levels are typically low except during pregnancy or certain leukemias.
Its secretion from the placenta during the third trimester increases plasma levels significantly, contributing to placental protection and prevention of metastatic cancer spread. PAI-2 also inhibits keratinocyte proliferation and participates in innate immune responses during viral infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.