Thermo Fisher Scientific HERPUD1 Polyclonal Antibody
HERPUD1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot, IHC(P), ICC/IF에 적합합니다. 인간에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. ER 스트레스 연구 및 UPR 관련 단백질 분석에 유용합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,500–1:5,000 | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HERPUD1. Recombinant protein control fragment (Product #RP-98601) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642400 |
Product Specific Information
Immunogen sequence:
LGPGFSGYTP YGWLQLSWFQ QIYARQYYMQ YLAATAASGA FVPPPSAQEI PVVSAPAPAP IHNQFPAENQ PANQNAAPQV VVNPGANQNL RMNAQGGPIV EEDDEINRD
Antigen sequence identity:
- Mouse: 94%
- Rat: 94%
Target Information
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes inhibition of translation to prevent further accumulation of unfolded proteins, increased expression of folding-related proteins (unfolded protein response, UPR), and degradation of misfolded proteins by the ER-associated degradation (ERAD) system.
HERPUD1 is involved in both UPR and ERAD. Its expression is induced by UPR and contains an ER stress response element in its promoter. The encoded protein has an N-terminal ubiquitin-like domain that may interact with the ERAD system. It interacts with presenilin proteins and can increase amyloid-beta protein levels upon overexpression.
Alternative splicing produces multiple transcript variants, though not all full-length forms have been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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