Thermo Fisher Scientific TRAF2 Polyclonal Antibody
TRAF2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, IP 등 다양한 응용에 적합하며 Human에 반응. 항원 친화 크로마토그래피로 정제된 액상 형태, 4°C 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 300 and 350 of Human TNF receptor-associated factor 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections
- Based on sequence identity, antibody predicted to react with Mouse
Target Information
Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are adaptor proteins that link the TNF receptor superfamily to signaling pathways, regulating cell death and stress responses. TRAF proteins share a conserved region enabling receptor and TRAF binding, activating diverse signal cascades.
TRAF2 and TRAF3 bind directly to CD40, a receptor critical for NF-κB activation in B lymphocytes. TRAF2, along with TRAF6, is required for CD40 signaling in non-hematopoietic cells. TRAF2 also interacts with the lymphotoxin-beta receptor (LTβR) alongside TRAF3 and apoptosis inhibitors cIAP1 and Smac.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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