Thermo Fisher Scientific CARD11 Polyclonal Antibody
CARD11 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 ICC/IF에 사용 가능. 인체 유래 펩타이드 면역원 기반으로 제작되었으며, Affinity chromatography로 정제됨. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CARD11 (Accession Q9BXL7), corresponding to amino acid residues E626–L676 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852246 |
Product Specific Information
Antibody detects endogenous levels of total CARD11.
Target Information
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, which functions as molecular scaffolds for assembling multiprotein complexes at specialized regions of the plasma membrane.
This protein is also a member of the CARD protein family, characterized by the caspase-associated recruitment domain (CARD).
CARD11 has a domain structure similar to CARD14 and specifically interacts with BCL10, a positive regulator of cell apoptosis and NF-kappaB activation.
When expressed in cells, CARD11 activates NF-kappaB and induces phosphorylation of BCL10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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