Thermo Fisher Scientific Human CAMK2A (CaMKII Alpha), His Tag Recombinant Protein

Thermo Fisher Scientific Human CAMK2A (CaMKII Alpha), His Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution

• Assay-dependent

Product Specifications

Product Specific Information

For maximum recovery, please spin prior to use.
Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use materials in original packaging until exhausted.
For larger sizes, reduce freeze/thaw cycles by preparing aliquots (not below 20 µL).
Do not store kinase diluted.
Properly stored at -80°C, product is guaranteed for 6 months from date of purchase.

Protein Form: Recombinant, Full Length

Target Information

CAMK2A (CaMKII alpha) is a serine/threonine kinase that regulates various cellular functions including:

• Neuronal processes and gene expression
• Carbohydrate metabolism and cytoskeletal function
• Calcium homeostasis

Autophosphorylation of threonine 286 in the presence of Ca²⁺ and calmodulin activates CAMK2A, enabling a switch from calmodulin-dependent to independent activity.
CaMKII plays roles in dendritic spine and synapse formation, neuronal plasticity, and regulation of sarcoplasmic reticulum Ca²⁺ transport in skeletal muscle.
In neurons, it contributes to actin cytoskeleton reorganization during plasticity by binding and bundling actin filaments in a kinase-independent manner.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.