Thermo Fisher Scientific Estrogen Receptor alpha Monoclonal Antibody (AER314)
Estrogen Receptor alpha 단백질을 인식하는 Mouse monoclonal antibody (Clone AER314). Western blot, Immunoprecipitation, Gel Shift 등 다양한 응용에 적합. Human, Mouse 등 여러 종에 반응하며 4°C에서 보관.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Estrogen Receptor alpha Monoclonal Antibody (AER314)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:400 | View 5 publications |
| Immunohistochemistry (IHC) | – | View 2 publications |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
| Immunoprecipitation (IP) | 2 µg/mL | View 1 publication |
| ChIP assay (ChIP) | – | View 4 publications |
| Gel Shift (GS) | 1 mg/mL | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Bovine, Hamster, Human, Mouse |
| Host / Isotype | Mouse / IgG1, lambda |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AER314 |
| Immunogen | Purified, SDS-denatured calf uterus estrogen receptor (ER) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
| RRID | AB_10984048 |
Product Specific Information
MA5-12328 targets Estrogen Receptor in WB, GS, and IP applications and shows reactivity with bovine, human, mouse, rabbit, and rat samples.
By Western blot, MA5-12328 detects recombinant ER alpha, but may not be suitable for detection of endogenous protein.
The MA5-12328 immunogen is purified, SDS-denatured calf uterus estrogen receptor (ER).
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors.
The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen, undergoes a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA.
This process regulates gene transcription through coactivator or corepressor recruitment.
There are two forms of the estrogen receptor, alpha (ESR1) and beta (ESR2).
At least four isoforms of estrogen receptor-alpha are known:
- Isoform 1 (66 kDa)
- Isoform 2 (53 kDa)
- Isoform 3 (47 kDa)
- Isoform 4 (35 kDa)
Estrogen receptors are expressed in various tissues and are essential for sexual development, reproductive function, and bone physiology.
They are implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.