Thermo Fisher Scientific alpha Actinin 2/3 Polyclonal Antibody
Rabbit polyclonal antibody targeting alpha Actinin 2/3. Suitable for WB, IHC, and ICC applications. Supplied as liquid, unconjugated form at 1 mg/mL. Ideal for research use in muscle and cytoskeletal protein studies.
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- PA538605
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- pk
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Thermo Fisher Scientific alpha Actinin 2/3 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the N-terminal region of human Actin alpha-2/3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555201 |
Target Information
Alpha actinins belong to the spectrin gene superfamily, representing a diverse group of cytoskeletal proteins including alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types.
In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it binds actin to the membrane.
In skeletal, cardiac, and smooth muscle, isoforms are localized to the Z-disc and analogous dense bodies, anchoring myofibrillar actin filaments.
This gene encodes a muscle-specific alpha actinin isoform expressed in both skeletal and cardiac muscles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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