Thermo Fisher Scientific Phospho-Chemerin Receptor 1 (Ser345, Ser346) Polyclonal Antibody
인간 CMKLR1 단백질의 Ser345/Ser346 인산화 부위를 인식하는 rabbit polyclonal 항체. Western blot에 적합하며, 1 mg/mL 농도의 액상 형태로 제공. 항원 친화 크로마토그래피로 정제되었으며, 단기 4°C, 장기 -20°C에서 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human CMKLR1 around the phosphorylation site Ser345/Ser346. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Chemokine-like receptor 1 (CMKLR1) is a receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid-derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK, and PI3K, leading to multifunctional effects like reduction of immune responses, enhancement of adipogenesis, and angiogenesis.
Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B.
CMKLR1 positively regulates adipogenesis and adipocyte metabolism and acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR, and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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