Thermo Fisher Scientific HRAS Monoclonal Antibody (OTI1A1), Biotin, TrueMAB
HRAS 단백질을 인식하는 Biotin 결합 단일클론 항체로 인간 시료에 반응합니다. Luminex 등 다양한 분석에 사용 가능하며, 고순도 친화 크로마토그래피로 정제되었습니다. 안정적인 PBS/BSA/glycerol 버퍼에 보존되어 연구용으로 적합합니다.
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Thermo Fisher Scientific HRAS Monoclonal Antibody (OTI1A1), Biotin, TrueMAB
Applications
- Luminex (LUM)
Tested Dilution: Assay-Dependent
Publications: 참고 문헌 보기
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A1 |
| Immunogen | Full-length human recombinant HRAS protein produced in HEK293T cells |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 10 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
Monomeric G protein Ras acts as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to downstream signaling pathways that lead to distinct cytoplasmic or nuclear events. Mammalian cells contain three Ras proto-oncogenes coding for closely related proteins: H-, K-, and N-Ras. Oncogenic mutations in Ras genes occur in approximately 30% of human cancers. Constitutive activation of Ras due to mutations or overexpression promotes proliferation and inhibits apoptosis.
- K-Ras mutations: Common in pancreatic, colorectal, and non-small-cell lung carcinomas
- H-Ras mutations: Common in bladder, kidney, and thyroid carcinomas
- N-Ras mutations: Found in melanoma, hematological malignancies, and hepatocellular carcinoma
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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