Thermo Fisher Scientific SHANK3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:10,000–1:25,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, predicted to react with Rat

Target Information

SHANK3 is a major scaffold postsynaptic density protein that interacts with multiple proteins and complexes to orchestrate dendritic spine and synapse formation, maturation, and maintenance. It interconnects postsynaptic receptors including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, and links to the actin-based cytoskeleton. SHANK3 plays a role in dendritic spine structural organization through interactions with Arp2/3 and WAVE1 complex, promoting F-actin clusters. It regulates neuron growth cone motility and NMDA receptor signaling, modulates GRIA1 exocytosis and GRM5/MGLUR5 expression, controlling synaptic transmission and plasticity. SHANK3 may be required at early synapse formation stages and inhibited by IGF1 to promote maturation. (Uniprot)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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