Thermo Fisher Scientific TNFSF11 Monoclonal Antibody (1D8)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
SKLEAQPFAH LTINATDIPS GSHKVSLSSW YHDRGWGKIS NMTFSNGKLI VNQDGFYYLY ANICFRHHET SGDLATEYLQ LMVYVTKTSI KIPSSHTLMK GGSTKYWSGN SEFHFYSINV GGFFKLRSGE EISIEVSNPS LLDPDQDATY FGAFKVRDID

Target Information

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation.
This protein was shown to be a dendritic cell survival factor and is involved in the regulation of T cell-dependent immune response.
T cell activation induces expression of this gene, leading to increased osteoclastogenesis and bone loss.
It activates antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and TRAF6, suggesting a role in apoptosis regulation.
Targeted disruption of the related gene in mice leads to severe osteopetrosis, lack of osteoclasts, defects in early T and B cell differentiation, and failure to form lobulo-alveolar mammary structures during pregnancy.
Two alternatively spliced transcript variants have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.