Thermo Fisher Scientific CBF-beta Polyclonal Antibody

Applications

Western Blot (WB)

• Assay-dependent

Immunoprecipitation (IP)

• 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family. This factor regulates genes related to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2).
The beta subunit is a non-DNA binding regulatory subunit that enhances DNA binding by the alpha subunit as the complex binds to core sites of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, and GM-CSF promoters.
Alternative splicing generates two mRNA variants encoding distinct carboxyl termini. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta fused with the C-terminal portion of smooth muscle myosin heavy chain 11, associated with acute myeloid leukemia (M4Eo subtype). Two transcript variants encoding different isoforms have been identified.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.