Thermo Fisher Scientific TAGLN2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, A549, HeLa, mouse brain
• Predicted reactivity: Human (99%), Mouse (95%), Rat (96%), Rhesus Monkey (99%), Bovine (98%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Transgelin (also designated SM22alpha) is abundantly expressed in smooth muscle cells.
Transgelin-2 (SM22alpha homolog) is a homolog of transgelin and is also expressed in smooth muscle cells and peritoneal B-1 cells.
The human transgelin-2 gene (TAGLN2), located on chromosome 1q23.1–q25, encodes a 199 amino acid protein containing a calponin-like repeat and a calponin-homology (CH) domain.
Transgelin-2 may function similarly to transgelin. During embryogenesis, transgelin is expressed in smooth, cardiac, and skeletal muscle, but later restricted to vascular and visceral smooth muscle cells.
Transgelin is downregulated in several transformed cell lines, suggesting that reduced expression may indicate early transformation.
It binds actin, inducing actin fiber gelation within minutes, with a binding ratio of 1:6 actin monomers.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.