Thermo Fisher Scientific FGF23 (Fibroblast Growth Factor 23) Monoclonal Antibody (FGF23/4174)
FGF23 단백질을 인식하는 Mouse monoclonal antibody로, 인간 시료에 반응합니다. IHC, Peptide Array, Immunoelectrophoresis 등 다양한 응용에 사용 가능하며, 고순도의 Protein A/G 정제 항체입니다. 연구용으로 안정적이며 4°C에서 보관됩니다.
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- 8074-MSM14-P1
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Thermo Fisher Scientific FGF23 (Fibroblast Growth Factor 23) Monoclonal Antibody (FGF23/4174)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | FGF23/4174 |
| Immunogen | Recombinant fragment (around aa100–225) of human FGF23 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: Human kidney tissue
- Cellular Localization: Secreted (extracellular)
- Specificity Comments:
Fibroblast growth factor-1 (FGF-1), also known as acidic FGF, and fibroblast growth factor-2 (FGF-2), known as basic FGF, belong to a family of growth factors that stimulate proliferation of mesenchymal, epithelial, and neuroectodermal cells. Additional family members include FGF-3 through FGF-23. These FGFs share 30–55% amino acid sequence identity and similar gene structures, and can transform cultured cells when overexpressed. Their receptors are tyrosine kinases such as FGFR-1 (Flg), FGFR-2 (Bek), TKF, and FGFR-3.
Target Information
The protein encoded by this gene is part of the fibroblast growth factor family, which has broad mitogenic and cell survival activities. FGF family members are involved in embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion.
FGF23 inhibits renal tubular phosphate transport and is associated with autosomal dominant hypophosphatemic rickets, a phosphate-wasting disorder. High expression levels of FGF23 are found in oncogenic hypophosphatemic osteomalacia. Mutations in this gene can also cause familial tumoral calcinosis with hyperphosphatemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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