
Thermo Fisher Scientific VKORC1 Polyclonal Antibody
VKORC1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF, ELISA, IP 등 다양한 응용에 사용 가능. 인간, 마우스, 랫트에 반응하며, 액상 형태로 -20°C 보관. 친화 크로마토그래피로 정제됨.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 10–60 of human VKORC1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA and 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Vitamin K epoxide reductase complex subunit 1 (VKORC1) is an enzyme responsible for reducing vitamin K 2,3-epoxide to its active form, essential for blood clotting. This reduced vitamin K is required for the carboxylation of glutamic acid residues in blood-clotting proteins. Deficiency or inhibition of VKORC1 (e.g., by warfarin) can cause fatal bleeding. Mutations in VKORC1 are associated with deficiencies in vitamin K-dependent clotting factors and warfarin resistance in humans and rats.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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