Thermo Fisher Scientific CYP2D6 Polyclonal Antibody
CYP2D6 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC(P), ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 1 mg/mL 농도의 액상 형태로, PBS 및 50% 글리세롤에 보관. 약물 대사 관련 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CYP2D6 (Accession P10635), corresponding to amino acid residues E257–M307 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899720 |
Product Specific Information
This antibody detects endogenous levels of total Cytochrome P450 2D6.
Target Information
Cytochrome P450 2D6 (CYP2D6) is a member of the cytochrome P450 superfamily of enzymes. These monooxygenases catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. CYP2D6 localizes to the endoplasmic reticulum and metabolizes approximately 20% of commonly prescribed drugs, including debrisoquine, sparteine, propafenone, and amitriptyline. The gene is highly polymorphic, with certain alleles causing a poor metabolizer phenotype. It is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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