Thermo Fisher Scientific TRIM72 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:1,000–1:2,500

Product Specifications

Product Specific Information

• Immunogen sequence:
  LEAHVEAKEP RALRSPERRP TRIGLYLSFG DGVLSFYDAS DADALVPLFA FHERLPRPVY PFFDVCWHDK GKNAQPLLLV GPE
• Highest antigen sequence identity to the following orthologs:
  Mouse – 84%, Rat – 84%

Target Information

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.