Thermo Fisher Scientific DCC Polyclonal Antibody
인간 DCC 단백질을 인식하는 Rabbit Polyclonal 항체로 IHC(P)에서 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(glycerol 포함) 용액 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장. 종간 반응성: 인간, 마우스, 랫트.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DCC. Recombinant protein control fragment (Product # RP-103895) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640417 |
Product Specific Information
Immunogen sequence:
ACVRPTHPLR SFANPLLPPP MSAIEPKVPY TPLLSQPGPT LPKTHVKTAS LGLAGKARSP LLPVSVPTAP EVSEESHKPT EDSANVYEQD DLSEQMAS
- Highest antigen sequence identity to the following orthologs:
- Mouse: 98%
- Rat: 98%
Target Information
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand.
The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction.
The protein partially localizes to lipid rafts and induces apoptosis in the absence of ligand.
It functions as a tumor suppressor and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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