Thermo Fisher Scientific DCC Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000-1:2,500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human DCC. Recombinant protein control fragment (Product #RP-103895). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DCC,uniProtId:P43146-1,ncbiNodeId:9606,antigenRange:1334-1431,antigenLength:1447,antigenImageFileName:PA5-64420_DCC_P43146-1_Rabbit.svg,antigenImageFileNamePDP:PA5-64420_DCC_P43146-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2640417

Product Specific Information

Immunogen sequence: ACVRPTHPLR SFANPLLPPP MSAIEPKVPY TPLLSQPGPT LPKTHVKTAS LGLAGKARSP LLPVSVPTAP EVSEESHKPT EDSANVYEQD DLSEQMAS

Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.

Target Information

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.