Thermo Fisher Scientific Phospho-PI3K p85/p55 (Tyr467, Tyr199, Tyr464) Polyclonal Antibody
PI3K p85/p55 단백질의 인산화 형태(Tyr467, Tyr199, Tyr464)를 인식하는 Rabbit Polyclonal Antibody. Western blot 및 ELISA에 적합. 인간, 생쥐, 랫트 반응성. 고순도 Affinity Chromatography 정제, PBS/glycerol 저장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around Y467/Y199/Y464 of human p85-alpha (NP_8526641) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.05 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914878 |
Product Specific Information
- Positive test controls include: HeLa, C2C12
- Immunogen sequence: DRLYEE
Target Information
Phosphoinositide 3-kinase (PI3K, phospho PI3K) binds to activated (phosphorylated) protein-Tyr kinases through its SH2 domain and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
Phospho PI3K is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
During insulin stimulation, it also binds to IRS-1. Growth factors and hormones trigger this phosphorylation event, coordinating cell growth, cell cycle entry, cell migration, and cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- PA5-121306_PI3K_p85p55_P27986-1_Rabbit.svg
- PA5-121306_PI3K_p85p55_P27986-1_Rabbit_PDP.jpeg
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