Thermo Fisher Scientific Slug Recombinant Rabbit Monoclonal Antibody (BLR139H)
Recombinant rabbit monoclonal antibody targeting human Slug (SNAI2). Validated for WB and IP applications. High purity, liquid form, 400 µg/mL concentration. Suitable for research on epithelial-mesenchymal transition and cancer progression.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunoprecipitation (IP)
- Tested Dilution: 20 µL/mg of lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR139H |
| Immunogen | Peptide representing a region between residue 75 and 125 of Human Zinc finger protein SNAI2 (Slug) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 400 µg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Slug (SNAI2) is a member of the Snail family of C2H2-type zinc finger transcription factors, involved in epithelial-mesenchymal transitions and neural tube formation during vertebrate embryogenesis. Its transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Slug binds E-box regions of promoters to repress transcription of genes like E-cadherin and Claudin-1. Expression of Slug in breast, esophageal, and colorectal carcinomas correlates with poor prognosis. Additionally, Slug protects hemopoietic progenitor cells from radiation-induced apoptosis by repressing p53-mediated transcription of Puma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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