Thermo Fisher Scientific GTF2B/TFIIB Polyclonal Antibody
Rabbit polyclonal antibody recognizing human GTF2B/TFIIB, validated for WB and IP. Antigen affinity purified, supplied as liquid at 1 mg/mL. Predicted cross-reactivity with mouse, rat, bovine, and orangutan. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 100 and 150 of human General Transcription Factor IIB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine, and Orangutan
Target Information
Ubiquitin is a 76 amino acid highly conserved eukaryotic polypeptide that selectively marks cellular proteins for proteolytic degradation by the 26S proteasome. This tagging regulates the concentration of key regulatory proteins by limiting their lifespans. Polyubiquitination involves activation, conjugation, and transfer steps mediated by E1, E2, and E3 enzymes, and can be reversed by deubiquitination enzymes. Ubiquitin modification participates in numerous cellular processes including:
- Cell cycle control
- Growth and differentiation
- Embryogenesis and apoptosis
- Signal transduction and DNA repair
- Transcription regulation and replication
- Transport, stress responses, immune response, and nervous system functions
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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