Thermo Fisher Scientific XPG Polyclonal Antibody
Thermo Fisher Scientific의 XPG Polyclonal Antibody는 인간 XPG 단백질을 인식하는 토끼 유래 다클론 항체로, IHC(P)에서 1:200~1:500 희석 비율로 사용됩니다. 항원 친화 크로마토그래피로 정제되었으며, PBS(40% 글리세롤) 버퍼에 보관됩니다. 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human XPG. Recombinant protein control fragment (Product # RP-95290) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649692 |
Product Specific Information
Immunogen sequence:
DDFSQYQLKG LLKKNYLNQH IEHVQKEMNQ QHSGHIRRQY EDEGGFLKEV ESRRVVSEDT SHYILIKGIQ AKTVAEVDSE SLPSSSKMHG MSFDVKSSPC E
Highest antigen sequence identity to orthologs:
- Mouse: 83%
- Rat: 83%
Target Information
Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight.
The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is essential for DNA repair of solar UV-induced DNA damages.
- XPG nuclease performs the 3′ incision during nucleotide excision repair of DNA.
- The enzyme cleaves DNA bubble structures near the junction of unpaired and duplex regions.
- A 29-amino acid region (residues 981–1009) contains PCNA binding activity.
- Arginine 992 (Arg992) is critical for PCNA binding.
- Replication Protein A (RPA) binds directly to XPA and XPG, both involved in excision repair.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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