Thermo Fisher Scientific RAB3IP Polyclonal Antibody
RAB3IP 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(Paraffin)에서 검증됨. Human, Mouse, Rat 시료에 반응하며, 고순도 Affinity Chromatography로 정제됨. PBS/glycerol buffer에 보관되며 연구용으로 적합.
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- PA599698
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RAB3IP (Accession Q96QF0), corresponding to amino acid residues L260–C310 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818631 |
Product Specific Information
Antibody detects endogenous levels of total RAB3IP.
Target Information
RAB3IP is a guanine nucleotide exchange factor (GEF) that may activate RAB8A and RAB8B. It promotes GDP-to-GTP exchange, converting inactive GDP-bound Rab proteins into active GTP-bound forms. RAB3IP mediates GDP release from RAB8A and RAB8B but not from RAB3A or RAB5. It modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42, and DNMBP, it promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation, and lumenogenesis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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