Thermo Fisher Scientific eIF3a Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Immunogen sequence:
LQNNTILRLL QQVSQIYQSI EFSRLTSLVP FVDAFQLERA IVDAARHCDL QVRIDHTSRT LSFGSDLNYA TREDAPIG

Target Information

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773).
The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC).
It stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition.
The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732).
Additionally, it specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, differentiation, and apoptosis, using different RNA stem-loop binding modes for translational activation or repression (PubMed:25849773, PubMed:27462815).
[UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.