Thermo Fisher Scientific p120/Catenin delta-1 (CTNND1) Recombinant Mouse Monoclonal Antibody (rCTNND1/6903)
Recombinant mouse monoclonal antibody targeting p120/Catenin delta-1 (CTNND1). Validated for IHC (P) and immunoelectrophoresis. High specificity for E-cadherin/catenin complex detection. Stable for 24 months and ideal for cancer research applications.
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Thermo Fisher Scientific p120/Catenin delta-1 (CTNND1) Recombinant Mouse Monoclonal Antibody (rCTNND1/6903)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rCTNND1/6903 |
| Immunogen | Recombinant fragment (around aa868–968) of human p120 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: Human colon tissue
- Cellular Localization: Cell surface and cytoplasm
Specificity Comments:
Alpha-catenin and beta-catenin bind to the intracellular domain of E-cadherin, while p120 catenin binds E-cadherin at a juxta-membrane site. This complex stabilizes tight junctions. In cells, p120 catenin localizes to the E-cadherin/catenin adhesion complex and associates with the cytoplasmic C-terminus of E-cadherin, potentially interacting with other cadherins.
p120 is a proliferation-associated nucleolar protein found in most human malignant tumors but not in resting normal cells. In colorectal cancer, altered p120 catenin localization correlates with loss of cytoplasmic E-cadherin. p120 staining aids in distinguishing ductal vs. lobular neoplasia in breast tissue and clarifies low-grade ductal carcinoma in situ from lobular neoplasia. Altered p120 catenin expression predicts poor outcomes in invasive breast cancer.
Target Information
Delta 1 Catenin is a tyrosine kinase substrate involved in cell transformation by SRC and receptor signaling through EGF, PDGF, CSF-1, and ERBB2. Catenin–cadherin complexes link to the actin filament network, crucial for cadherin-mediated cell adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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