Thermo Fisher Scientific HO-1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Heme Oxygenase-1 (HO-1). Validated for WB and IP applications. Supplied as liquid, 1 mg/mL concentration. Recommended storage at 4°C. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 238 and 288 of human Heme Oxygenase (decycling) 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Heme oxygenase (HO) is a microsomal enzyme that catalyzes the oxidation of heme to the antioxidant molecules biliverdin and carbon monoxide. HO consists of two homologous isozymes: an inducible HO-1 and a constitutively expressed HO-2.
HO-1 is induced by a wide variety of stimuli including oxidative stress, inflammatory agents, transforming growth factor beta, and heat shock. The increase in HO-1 expression is considered a cellular defense mechanism against oxidative stress, as elevated HO may generate more bilirubin, an antioxidant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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