Thermo Fisher Scientific TRPC6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

TRPC6 forms a receptor-activated calcium channel in the cell membrane. The TRPC6 channel is activated by diacylglycerol (DAG) and is regulated by a phosphatidylinositol second messenger system. Activation occurs independently of protein kinase C and is not triggered by low intracellular calcium levels.
Mutations in the TRPC6 gene are associated with focal segmental glomerulosclerosis 2 (FSGS2). TRPC6 belongs to the mammalian transient receptor potential (TRP) superfamily, specifically the canonical TRP (TRPC) family, which includes seven members activated through PLC-coupled receptors.
Members of the TRPC3/6/7 subfamily can be activated by DAG analogs, suggesting a mechanism of activation via PLC-coupled receptors. In transfected cells, TRPC6 functions as a non-selective, store-independent, receptor-activated cation channel. It is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation.
TRPC6 encodes endogenous DAG-activated receptor-operated cation channels in vivo. Diseases associated with TRPC6 include Glomerulosclerosis, Focal Segmental, 2 and Focal Segmental Glomerulosclerosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.