Thermo Fisher Scientific Human TEM5 Synthetic Peptide
Human TEM5 단백질의 C-말단 15개 아미노산 서열에 해당하는 합성 펩타이드. 항체 PA5-20441의 블로킹 펩타이드로 사용 가능. 액상 형태, PBS(pH 7.2) + 0.1% BSA, 0.02% sodium azide 포함. -20°C 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the carboxy terminus of human TEM5.
PEP-0558 can be used as a blocking peptide with polyclonal antibody PA5-20441.
Target Information
Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogenesis, which are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. These include TEMs such as TEM1, TEM5, TEM7, and TEM8.
TEM5 is a member of the adhesion family of G protein-coupled receptors and is localized on the surface of endothelial cells. It is a seven-pass transmembrane receptor, unlike TEM1, TEM7, and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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